Regular Article TRANSFUSION MEDICINE Alloantibodies to a paternally derived RBC KEL antigen lead to hemolytic disease of the fetus/newborn in a murine model
نویسندگان
چکیده
Department of Pathology and Laboratory Medicine, Center for Transfusion and Cellular Therapies, and Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Division of Pediatric Hematology/Oncology, Emory University School of Medicine, Atlanta, GA; New York Blood Center, New York, NY; Biomedical Imaging Technology Core, Emory University and Georgia Institute of Technology, Atlanta, GA; Department of Pathology, Children’s Healthcare of Atlanta, Atlanta, GA; and Puget Sound Blood Center Research Institute, Seattle, WA
منابع مشابه
Alloantibodies to a paternally derived RBC KEL antigen lead to hemolytic disease of the fetus/newborn in a murine model.
Exposure to nonself red blood cell (RBC) antigens, either from transfusion or pregnancy, may result in alloimmunization and incompatible RBC clearance. First described as a pregnancy complication 80 years ago, hemolytic disease of the fetus and newborn (HDFN) is caused by alloimmunization to paternally derived RBC antigens. Despite the morbidity/mortality of HDFN, women at risk for RBC alloimmu...
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BACKGROUND Red blood cell (RBC) alloantibodies to nonself antigens may develop after transfusion or pregnancy, leading to morbidity and mortality in the form of hemolytic transfusion reactions or hemolytic disease of the newborn. A better understanding of the mechanisms of RBC alloantibody induction, or strategies to mitigate the consequences of such antibodies, may ultimately improve transfusi...
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